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货号: STA00526
货期: 次日发货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类:
靶点: Caspase-8
应用: WB
反应性 : Human
宿主物种 : Rabbit
MW(Observed): 55kDa
同种型-Isotype : IgG
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:500~1:2000
纯化工艺 : Affinity-chromatography
储存 : Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
克隆性 : Monoclonal
抗原&靶点信息
特异性 : Caspase-8 Antibody detects endogenous levels of Caspase-8
别名 : CASP8; ALPS2B; Apoptotic protease Mch-5; Apoptotic cysteine protease; Casp-8; Caspase-8; CAP4; Caspase 8; MACH; MCH5; Pro Caspase 8; FADD-like ICE; FLICE;
数据库链接:
背景:
Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10 (1-3). Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage.


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