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货号: PL1242
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类:
靶点: CD45
应用: WB,IHC,IF,ELISA
反应性 : Human,
宿主物种 : Rabbit
MW(CalcμLated) : 147kD
MW(Observed): 240-200kD
同种型-Isotype : IgG,Kappa
偶联-Conjugate : Unmodified
隐藏域元素占位
详细信息
推荐稀释比 : IHC 1:1000-1:10000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein A
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
克隆号 : PT0471R
抗原&靶点信息
特异性 : Endogenous
基因名称 : PTPRC
蛋白名称 : Receptor-type tyrosine-protein phosphatase C (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)
别名 : B220;CD 45;CD45;CD45 antigen;CD45R;GP180;L-CA;LCA;Leukocyte common antigen;loc;Ly-5;LY5;Ly5, homolog of;Lyt-4;OTTHUMP00000033813;OTTHUMP00000033816;OTTHUMP00000033817;OTTHUMP00000038574;Protein tyrosine phosphatase receptor type c polypeptide;Protein tyrosine phosphatase, receptor type C;protein tyrosine phosphatase, receptor type, C;Protein tyrosine phosphatase, receptor type, c polypeptide;Ptprc;PTPRC_HUMAN;Receptor-type tyrosine-protein phosphatase C;T200;T200 glycoprotein;T200 leukocyte common antigen
背景:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which enc


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