产品服务
信号通路
详细信息
修饰-Modification : Ser139
推荐稀释比 : IHC 1:2000-1:8000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200,
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein A
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
克隆号 : PT0330R
抗原&靶点信息
特异性 : This antibody detects endogenous levels of Histone H2A.X only when phosphorylated at Ser139.This antibody does not recognize phosphorylated at other sites.
基因名称 : H2AFX
蛋白名称 : Histone H2A.x
别名 : H2AFX;H2AX;Histone H2A.x;H2a/x,γ-H2AX,
背景:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Oct 2015],


微信客服