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Chk1 (Phospho Ser345) Rabbit mAb

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说明书下载
货号: PL1065
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
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靶点: Chk1 Phospho Ser345
应用: WB,IF,ELISA
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(CalcμLated) : 56kD
MW(Observed): 56kD
同种型-Isotype : IgG,Kappa
偶联-Conjugate : Phospho

隐藏域元素占位

详细信息

修饰-Modification : Ser345
推荐稀释比 : WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein A
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
克隆号 : PT0651R

抗原&靶点信息

特异性 : Phospho-Chk1 (S345) Antibody detects endogenous levels of Chk1 protein only when phosphorylated at S345.
基因名称 : CHEK1
蛋白名称 : Serine/threonine-protein kinase Chk1
别名 : CHEK1;CHK1;Serine/threonine-protein kinase Chk1;CHK1 checkpoint homolog;Cell cycle checkpoint kinase;Checkpoint kinase-1

数据库链接:

Organism

基因 ID

SwissProt

背景:

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011],

细胞定位 : Nucleus . Chromosome . Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Nuclear export is mediated at least in part by XPO1/CRM1 (PubMed:12676962). Also localizes to the centrosome specifically during interphase, where it may protect centrosomal CDC2 kinase from inappropriate activation by cytoplasmic CDC25B (PubMed:15311285). Proteolytic cleavage at the C-terminus by SPRTN promotes removal from chromatin (PubMed:31316063). .

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