产品服务
信号通路
说明书下载
货号: TPFL0356
货期: 现货
价格: 1650;950
所属分类:
靶点: Iba1
应用: IHC(PFA fixed)/IF(PFA fixed)
反应性 : H,M,R,Mk
宿主物种 : Mouse
同种型-Isotype : IgG1, κ
隐藏域元素占位
详细信息
推荐稀释比 : IHC/IF 1:500-1:4000
组成 : PBS containing 0.15% ProClin 300, 100 μg/mL BSA and 50% glycerol.
纯化工艺 : Affinity Purification
储存 : Form: Liquid,Shipping condition: Blue Ice,Short-term storage (1–2 weeks): +4°C,Long-term storage: -20°C,Aliquot information:,Aliquot upon delivery,Storage note: Avoid freeze-thaw cycles.
克隆性 : Monoclonal
克隆号 : 5G4E7
抗原&靶点信息
基因名称 : AIF1
蛋白名称 : Allograft inflammatory factor 1
别名 : AIF-1, IBA, IRT-1, IRT1, allograft, AIF-1, AIF1, G1, IBA1, IRT 1, Protein G1, Ionized calcium-binding adapter molecule 1, MRF1, Microglia response factor, BART 1, AIF1 protein
背景:
AIF1, also named as G1, IBA1 or daintain/AIF-1, is a 143 amino acid cytoplasmic, inflammation response scaffold protein. It is constitutively expressed in monocytes and macrophages and is known to be involved in macrophage activation. It is a marker of activated macrophage. Despite a lack of detailed knowledge on the in vivo physiological functions of AIF-1, there is growing evidence that shows its aberrant expression contributes to the pathogenesis of many autoimmune diseases, including rheumatoid arthritis. AIF1 is an actin-binding protein that enhances membrane ruffling and RAC activation. It enhances lymphocyte migration and the actin-bundling activity of LCP1. | |


微信客服