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SOCS3

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货号: TPFL0312
货期: 现货
价格: 1350;2200;3000
+

所属分类:


靶点: SOCS3
应用: WB, IHC, IF-P, ELISA
反应性 : human, mouse
宿主物种 : Mouse
MW(CalcμLated) : 25 kDa
MW(Observed): 25 kDa
同种型-Isotype : IgG1
偶联-Conjugate : Unconjugated

隐藏域元素占位

详细信息

组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Protein G purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 2000 ug/ml
克隆性 : Monoclonal

抗原&靶点信息

基因名称 : SOCS3
蛋白名称 : suppressor of cytokine signaling 3
别名 : 1G2B12, ATOD4, CIS3, CIS-3, Cytokine-inducible SH2 protein 3

数据库链接:

Organism

基因 ID

SwissProt

背景:

Suppressor of cytokine signaling 3 (SOCS3) is a member of SOCS family that these proteins induced to attenuate cytokine signal transduction in response to signals from a diverse range of cytokines and growth factors. SOCS3 is a negative regulatory protein that inhibits signaling induced by IL-6 via preventing JAK mediated activation of STAT3. However SOCS3 can positively regulate the ERK-MAPK pathway, inhibit the NF-kB pathway (PMID:26429311,25035930). In addition, SOCS3 brings a great impact on immune responses by inhibiting signaling stimulus, such as LPS, type I and type II IFNs, and IL-12. SOCS3 is widely expressed in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney (PMID: 22961088). Dysregulation of SOCS3 functions can cause a variety of diseases, including allergy, autoimmune diseases, inflammation and cancer (PMID:26429311).

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