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货号: TPFL0261
货期: 现货
价格: 1280;2180;2800
所属分类:
靶点: SLC2A1
应用: WB, IHC-P, IF/ICC, FCM
反应性 : human, mouse, rat
宿主物种 : Rabbit
MW(CalcμLated) : 54 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 : Western blot (WB): 1:500-2000; Immunohistochemistry (IHC): 1:50-400; Immunocytochemistry/Immunofluorescence (ICC/IF): 1:50-400; Flow Cytometry (Fixed): 1:50-200
组成 : 500 ug/ml antibody with PBS, 0.02% NaN3, 1 mg/ml BSA and 50% glycerol.
纯化工艺 : Immunogen affinity purified.
储存 : 12 months from date of receipt,-20℃ as supplied.
浓度 : 500 ug/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : SLC2A1
蛋白名称 : Solute carrier family 2, facilitated glucose transporter member 1
别名 : DYT17; DYT18; GLUT; GLUT 1; GLUT1; HepG2 glucose transporter; PED; SLC2A1
背景:
GLUT1, also known as SLC2A1, is a major glucose transporter in the mammalian blood-brain barrier whose gene is mapped to 1p35-p31.3 and contains 10 exons. It is present at high levels in primate erythrocytes and brain endothelial cells. Not only can transport dehydroascorbic acid (the oxidized form of vitamin C) into the brain, GLUT1 is also likely to contribute to HTLV-associated disorders through interacting with HTLV envelope glycoproteins. Functionally, GLUT1 deficiency causes a decrease in embryonic glucose uptake and apoptosis, which may be involved in diabetic embryopathy, by contrast, an increased expression of GLUT1 in some malignant tumors may suggest a role for glucose-derivative tracers to detect in vivo thyroid cancer metastases by positron-emission tomography scanning.


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