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Anti-keap1 Rabbit pAb

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说明书下载
货号: TPFL0259
货期: 现货
价格: 1650;950
+

所属分类:


靶点: keap1
应用: IHC/IF
反应性 : H,M,R
宿主物种 : Rabbit
同种型-Isotype : IgG

隐藏域元素占位

详细信息

推荐稀释比 : IHC/IF 1:750-1:3000
组成 : PBS containing 0.15% ProClin 300, 100 μg/mL BSA and 50% glycerol.
纯化工艺 : Affinity Purification
储存 : Form: Liquid,Shipping condition: Blue Ice,Short-term storage (1–2 weeks): +4°C,Long-term storage: -20°C,Aliquot information:,Aliquot upon delivery,Storage note: Avoid freeze-thaw cycles.
克隆性 : Polyclonal

抗原&靶点信息

基因名称 : KEAP1
蛋白名称 : Kelch-like ECH-associated protein 1
别名 : keap1, INrf2, KLHL19, Kelch like ECH associated protein 1, KIAA0132, Cytosolic inhibitor of Nrf2

数据库链接:

Organism

基因 ID

SwissProt

Mus musculus
背景:

Keap1 has been shown to interact with Nrf2, a master regulator of the antioxidant response, which is important for the amelioration of oxidative stress. Under quiescent conditions, Nrf2 is anchored in the cytoplasm through binding to Keap1, which in turn facilitates the ubiquitination and subsequent proteolysis of Nrf2. Such sequestration and further degradation of Nrf2 in the cytoplasm are mechanisms for the repressive effects of Keap1 on Nrf2. | |

细胞定位 : cytoplasm, nucleus

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