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货号: TPFL0247
货期: 现货
价格: 1280;2180;2800
所属分类:
靶点: PARP1
应用: WB, IHC-P, IF/ICC, FCM
反应性 : human, mouse, rat
宿主物种 : Rabbit
MW(CalcμLated) : 113 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 : Western blot (WB): 1:500-2000; Immunohistochemistry (IHC): 1:50-400; Immunocytochemistry/Immunofluorescence (ICC/IF): 1:50-400; Immunofluorescence (IF): 1:50-400; Flow Cytometry (Fixed): 1:50-200
组成 : 500 ug/ml antibody with PBS, 0.02% NaN3, 1 mg/ml BSA and 50% glycerol.
纯化工艺 : Immunogen affinity purified.
储存 : 12 months from date of receipt,-20℃ as supplied.
浓度 : 500 ug/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : PARP1
蛋白名称 : Poly [ADP-ribose] polymerase 1
别名 : ADPRT; ADPRT 1; ADPRT1; pADPRT 1; PARP; PARP 1; PARP1; poly (ADP ribose) polymerase 1; Poly [ADP ribose] polymerase 1; Poly[ADP ribose] synthase 1; PPOL
背景:
Poly [ADP-ribose] polymerase 1 (PARP1), also known as ADPRT or PPOL is an enzyme that in humans is encoded by the PARP1 gene. PARP1 gene is mapped to 1q42.12. This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.


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