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货号: TPFL0233
货期: 现货
价格: 1350;2200;3000
所属分类：
靶点: Beclin 1
应用： WB, IHC, IF/ICC, IF-P, IF-Fro, IP, ELISA
反应性 ： human, mouse, rat
宿主物种 ： Rabbit
MW(CalcμLated) ： 52 kDa
MW(Observed)： 52-60 kDa
同种型-Isotype ： IgG
偶联-Conjugate ： Unconjugated
隐藏域元素占位
详细信息
组成 ： PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 ： Antigen affinity purification
储存 ： Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 ： 600 ug/ml
克隆性 ： Polyclonal
抗原&靶点信息
基因名称 ： Beclin 1
蛋白名称 ： beclin 1, autophagy related
别名 ： BECN1, Beclin-1-C 37 kDa, Beclin-1-C 35 kDa, Beclin-1, Beclin1
背景：
Beclin 1, also known as ATG6 or VPS30, interacts with various cofactors (e.g. Ambra1, Barkor (Atg14), Rubicon, or UVRAG) to regulate the lipid kinase Vps34 and promote the formation of the BECLIN1-Vps34-Vps15 complex, hence inducing autophagy. Its function (via the BH3 domain) is inhibited by Bcl-2 or Bcl-XL. Beclin 1 (BECN1) is a crucial molecule in the control of the autophagic activity, and its activity is regulated by multiple mechanisms, including the post-translational modification, protein-protein interaction, and subcellular localization. It plays a role in crosstalk between apoptosis and autophagy. It has been reported that Beclin 1 can be cleaved into fragments of 50, 37 and 35 kDa during apoptosis. It is involved in many disorders, including neurodegeneration and cancer (tumorigenesis). Beclin 1 is a mammalian tumor suppressor, and its gene is monoallelically deleted in 75% of ovarian, 50% of breast, and 40% of prostate cancers. Decreased expression of Beclin 1 has also been observed in human brain and lung tumors. The level of Beclin 1 was decreased in the affected brain regions of patients with Alzheimer's disease early in the disease process. Recent studies have also shown that gain and loss of Beclin 1 function affects the death of heart cells.
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