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货号: TPFL0231
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: Beta Catenin
应用: WB, IHC, IF/ICC, IF-P, FC , IP, ELISA
反应性 : human, mouse, rat, pig
宿主物种 : Rabbit
MW(CalcμLated) : 781 aa, 86 kDa
MW(Observed): 92 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 500 ug/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : Beta Catenin
蛋白名称 : catenin (cadherin-associated protein), beta 1, 88kDa
别名 : b cat, B-catenin, beta-Catenin, Catenin beta 1, Catenin beta-1
背景:
β-Catenin, also known as CTNNB1, is an evolutionarily conserved, multifunctional intracellular protein. β-Catenin is a 92-kDa protein, originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. The Wnt/β-catenin pathway is also involved in the activation of other intracellular messengers such as calcium fluxes, JNK, and SRC kinases. Deregulation of β-catenin activity is associated with multiple diseases including cancers. (PMID: 22617422; 18334222)


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