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货号: TPFL0218
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: CD45
应用: WB, IHC, IF/ICC, IF-P, IF-Fro, IP, ELISA
反应性 : human, mouse, rat
宿主物种 : Rabbit
MW(CalcμLated) : 1304 aa, 147 kDa
MW(Observed): 180-220 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 540 ug/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : CD45
蛋白名称 : protein tyrosine phosphatase, receptor type, C
别名 : EC:3.1.3.48, GP180, L CA, LCA, L-CA
背景:
Protein tyrosine phosphatase receptor type C (PTPRC) is also known as CD45 antigen, which was originally called leukocyte common antigen (LCA). CD45 is an enzyme required for T-cell activation through the antigen receptor consisting of two intracellular phosphatase domains, a transmembrane domain and an extracellular domain. Upon T-cell activation, CD45 recruits and dephosphorylates SKAP1 via an interaction through the first PTPase domain, which is the only domain to possess intrinsic kinase activity. However, both domains are required for appropriate phosphatase and T-cell antigen receptor activity (PMID: 8076596).


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