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货号: TPFL0213
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: CHOP
应用: WB, IHC, IF/ICC, FC , IP, ELISA
反应性 : human, mouse, rat
宿主物种 : Rabbit
MW(CalcμLated) : 19 kDa
MW(Observed): 30 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 700 ug/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : CHOP
蛋白名称 : DNA-damage-inducible transcript 3
别名 : CHOP; GADD153, CHOP, DDIT3, GADD153, C/EBP zeta
背景:
CHOP, also known as GADD153 or DDIT3, is a highly conserved gene in both the structural and regulatory regions. Imposed by unfolded and misfolded proteins, CHOP is significantly induced by ER stress. CHOP is considered a proapoptotic marker of ER stress dependent cell death. CHOP acts as a dominant-negative inhibitor of the transcription factor C/EBP and LAP. It may play an important role in the malignant transformation of nevus to melanoma. The calculated molecular weight of CHOP is 19 kDa, but the protein migrates on an SDS-PAGE gel with an observed molecular mass of 29 kDa (PMID: 1547942).


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