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货号: TPFL0181
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: HO-1
应用: WB, IHC, IF-P, IF-Fro, FC , IP, ELISA
反应性 : human, mouse, rat
宿主物种 : Rabbit
MW(CalcμLated) : 33 kDa
MW(Observed): 28-33 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 800 ug/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : HO-1
蛋白名称 : heme oxygenase (decycling) 1
别名 : HMOX1, HO-1, bK286B10, EC:1.14.14.18, heme oxygenase (decycling) 1
背景:
Heme oxygenase (HMOX1) catalyzes the first and rate-limiting step in the degradation of heme to yield equimolar quantities of biliverdin Ixa, carbon monoxide (CO), and iron. It has 3 isoforms: HO-1 is highly inducible, whereas HO-2 and HO-3 are constitutively expressed (PMID:10194478). Heme oxygenase-1 (HO-1) is expressed in many tissues and vascular smooth muscle cells, and endothelial cells (PMID:15451051) and has been identified as an important endogenous protective factor induced in many cell types by various stimulants, such as hemolysis, infiammatory cytokines,oxidative stress, heat shock, heavy metals, and endotoxin (PMID: 11522663). And the full-length HO-1 is very unstable and susceptible to truncation that generates an inactive, soluble form (28 kDa) (James R. Reed, Pharmacology, 535-568).


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