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货号: TPFL0180
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: HSP90
应用: WB, IHC, IF/ICC, FC , IP, ELISA
反应性 : human, mouse, rat
宿主物种 : Rabbit
MW(CalcμLated) : 853 aa, 90 kDa
MW(Observed): 90 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 830 ug/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : HSP90
蛋白名称 : heat shock protein 90kDa alpha (cytosolic), class A member 1
别名 : HSP90AA1, EC:3.6.4.10, Heat shock protein family C member 1, Heat shock protein HSP 90 alpha, Heat shock protein HSP 90-alpha
背景:
HSP90, encoded by HSP90AA1, is a constitutively and ubiquitously expressed molecular chaperone that is crucial for the stability and function of many proteins. HSP90 provides chaperoning activity for client proteins; many of them are members of oncogenic pathways, indicating its implication in tumor malignancy. HSP90 mainly resides in the cytosol, while it can also be released to the extracellular space. Secreted Hsp90 is a C-terminal truncated form. It has been reported that the level of plasma Hsp90 is positively correlated with tumor malignancy in clinical cancer patients, and can be a promising diagnostic marker for tumor malignancy in clinical application. This antibody may cross-react with HSP90AB1 due to the high homology between them.


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