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MUC1/CA15-3 C-terminal Polyclonal antibody

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货号: TPFL0163
货期: 现货
价格: 1350;2200;3000
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靶点: MUC1/CA15-3
应用: WB, IHC, ELISA
反应性 : human
宿主物种 : Rabbit
MW(CalcμLated) : 1264 aa, 123 kDa
MW(Observed): 23-28 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated

隐藏域元素占位

详细信息

组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 750 ug/ml
克隆性 : Polyclonal

抗原&靶点信息

基因名称 : MUC1/CA15-3
蛋白名称 : mucin 1, cell surface associated
别名 : CA153, CA15-3, MUC1, Breast carcinoma-associated antigen DF3, CA 15-3

数据库链接:

Organism

基因 ID

SwissProt

背景:

MUC1 is a type I transmembrane glycoprotein expressed by various epithelial cells of the female reproductive tract, lung, breast, kidney, stomach, and pancreas. MUC1 is transcribed as a large precursor gene product, and upon translation, is cleaved in the endoplasmic reticulum, yielding two subunits: the large extracellular N-terminal subunit (MUC1-N, about 120-200 kDa) and the small cytoplasmic C-terminal subunit (MUC1-C, about 23-30 kDa). Among the known mucins, MUC1 is best studied and plays crucial roles in regulating many cellular properties, including cell proliferation, apoptosis, adhesion, and invasion. MUC1 is overexpressed in a wide range of human epithelial malignancies. This antibody was raised against the C-terminal region of human MUC1, thus it recognizes the 23-30 kDa cytoplasmic MUC1.

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