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货号: TPFL0156
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: NOX1
应用: WB, IHC, ELISA
反应性 : human, mouse, rat
宿主物种 : Rabbit
MW(CalcμLated) : 564 aa, 65 kDa
MW(Observed): 59 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 650 ug/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : NOX1
蛋白名称 : NADPH oxidase 1
别名 : EC:1.6.3.-, GP91 2, Mitogenic oxidase 1, MOX 1, MOX1
背景:
NNOX1(NADPH oxidase 1) is also named as MOX1, NOH1 and belongs to the reactive oxygen species (ROS)-generating NADPH oxidase family. It plays a role in host defense, cell growth and differentiation, cell migration, and malignant transformation(PMID:20351171). It also can mediate oncogenic Ras-induced upregulation of VEGF and angiogenesis by activating Sp1 through Ras-ERK-dependent phosphorylation of Sp1(PMID:18454179). It has 3 isoforms produced by alternative splicing with the molecular weight of 65 kDa, 22 kDa and 59 kDa. The full length protein has two glycosylation sites. It always can be detected two bands of 63 kDa and 55 kDa in cells by western blot or another lower band of 45 kDa which is not likely due to alternative translation or splice variation, but as adjustment for the signal peptide and tag removal(PMID:17560373) or unspecifc(PMID:17460729).


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