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货号: TPFL0150
货期: 现货
价格: 1180.00;1980.00;2800.00
所属分类：
靶点: Pan Cytokeratin
应用： WB, IHC-P, IHC-F, IF, Flow-Cyt, ICC/IF
反应性 ： Human,Mouse,Rat
宿主物种 ： Rabbit
MW(CalcμLated) ： 42-64 kDa
MW(Observed)： 46,60 kDa
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:500-2000; IHC-P 1:100-500; IHC-F 1:100-500; IF 1:100-500; Flow-Cyt 1μg /test; ICC/IF 1:100-500
组成 ： 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
纯化工艺 ： affinity purified by Protein A
储存 ： Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
浓度 ： 1mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
基因名称 ： Pan Cytokeratin
蛋白名称 ： Pan Cytokeratin Rabbit pAb
别名 ： CK13; K13; WSN2; K1C16_HUMAN; KRT16; Cytokeratin-16 (CK-16); Keratin-16 (K16); KRT16A; CK14; EBS1; EBS1A; EBS1B; EBS1C; EBS1D; EBS3; EBS4; K14; NFJ; K1C14_HUMAN; KRT14; Cytokeratin-14 (CK-14); Keratin-14 (K14); CK16; FNEPPK; K16; K1CP; NEPPK; PC1; 39.1; CK-17; K17; PC; PC2; PCHC1; K1C17_HUMAN; KRT17; Cytokeratin-17 (CK-17); Keratin-17 (K17); CK-24; K24; KA24; K1C24_HUMAN; KRT24; Cytokeratin-24 (CK-24); Keratin-24 (K24); Type I keratin-24; keratin 24; keratin 24, type I; pan-cytokeratin; pan-CK; pan CK; P-CK; CK-PAN; wide spectrum Cytokeratin; Cytokeratins
数据库链接：
Organism
基因 ID
SwissProt
背景：
Cytokeratins are proteins of keratin-containing intermediate filaments found in the intracytoplasmic cytoskeleton of epithelial tissue. The cytokeratins are encoded by a family encompassing 30 genes. Among them, 20 are epithelial genes and the remaining 10 are specific for trichocytes. In the cytoplasm, the keratin filaments conform a complex network which extends from the surface of the nucleus to the cell membrane. Numerous accessory proteins are involved in the genesis and maintenance of such structure. This association between the plasma membrane and the nuclear surface provides important implications for the organization of the cytoplasm and cellular communication mechanisms. Apart from the relatively static functions provided in terms of supporting the nucleus and providing tensile strength to the cell, the cytokeratin networks undergo rapid phosphate exchanges mediated depolymerization, with important implications in the more dynamic cellular processes such as mitosis and post-mitotic period, cell movement and differentiation. Cytokeratins interact with desmosomes and hemidesmosomes, thus collaborating to cell-cell adhesion and basal cell-underlying connective tissue connection.
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