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货号: TPFL0149
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: Parkin
应用: WB, IHC, IF/ICC, IF-P, ELISA
反应性 : human, mouse, rat, pig
宿主物种 : Rabbit
MW(CalcμLated) : 52 kDa
MW(Observed): 42-52 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 950 ug/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : Parkin
蛋白名称 : Parkinson disease (autosomal recessive, juvenile) 2, parkin
别名 : PARK2, Parkin, E3 ubiquitin-protein ligase parkin, EC:2.3.2.31, Parkin RBR E3 ubiquitin-protein ligase
背景:
Parkin, a RING-type E3 ubiquitin-protein ligase, is involved in the ubiquitination pathway and contributes to protection from neurotoxicity induced by unfolded protein stresses. Its ubiquitin-protein ligase activity promotes the degradation of a variety of proteins including itself. Mutations in Parkin are implicated in the pathogenesis of autosomal recessive familial Parkinson's disease. It has 8 isoforms produced by alternative splicing with molecular weights of 24, 31, 36 and 42-52 kDa. Sometimes an additional band of 70 kDa or 110 kDa may be detected, which is caused by ubiquitination modification or formation of Parkin complex (PMID: 10976934, PMID: 18190519).


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