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货号: TPFL0148
货期: 现货
价格: 980;4000;6000
所属分类：
靶点: PCNA
应用： WB, IHC, IF-P, IP, ELISA
反应性 ： human, mouse, rat
宿主物种 ： Rabbit
MW(CalcμLated) ： 29 kDa/31 kDa
MW(Observed)： 36-38 kDa
同种型-Isotype ： IgG
偶联-Conjugate ： Unconjugated
隐藏域元素占位
详细信息
组成 ： PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 ： Antigen affinity purification
储存 ： Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 ： 560 ug/ml
克隆性 ： Polyclonal
抗原&靶点信息
基因名称 ： PCNA
蛋白名称 ： proliferating cell nuclear antigen
别名 ： Cyclin, proliferating cell nuclear antigen
背景：
Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase δ in eukaryotic cells. This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. PCNA induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. It has to be loaded onto DNA in order to be able to stimulate APEX2. PCNA protein is highly conserved during evolution; the deduced amino acid sequences of rat and human differ by only 4 of 261 amino acids. PCNA has been used as loading control for proliferating cells. This antibody is a rabbit polyclonal antibody raised against an internal region of human PCNA. The calculated molecular weight of PCNA is 29 kDa, but modified PCNA is 36kDa (PMID: 1358458).
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