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货号: TPFL0123
货期: 现货
价格: 1350;2200;3000
所属分类：
靶点: SIRT1
应用： WB, IHC, IF/ICC, IP, ELISA
反应性 ： human
宿主物种 ： Rabbit
MW(CalcμLated) ： 747 aa, 82 kDa
MW(Observed)： 110-130 kDa, 80-85 kDa
同种型-Isotype ： IgG
偶联-Conjugate ： Unconjugated
隐藏域元素占位
详细信息
组成 ： PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 ： Antigen affinity purification
储存 ： Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 ： 1200 ug/ml
克隆性 ： Polyclonal
抗原&靶点信息
基因名称 ： SIRT1
蛋白名称 ： sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
别名 ： EC:2.3.1.-, EC:2.3.1.286, hSIR2, hSIRT1, NAD-dependent protein deacetylase sirtuin-1
背景：
SIRT1, also named SIR2L1, contains a deacetylase sirtuin-type domain and belongs to the sirtuin family. The post-translation modified SIRT1 is a 110-130 kDa protein, which contains one deacetylase sirtuin-type domain.After phosphorylation modification, this target protein may present double bands ranging from 110 to 120 kDa. The 75-80 kDa SirT1 fragment was detected to lack the carboxy-terminus (PMID:21305533). SirT1 exists a 57-61 kDa isoform. SIRT1 may be found in nucleolus, nuclear euchromatin, heterochromatin, and inner membrane. It can shuttle between the nucleus and cytoplasm. SIRT1 regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. SIRT1 in particular initiates several signaling events relevant to cardioprotection, including activation of endothelial nitric oxide synthase, INS receptor signaling, and autophagy. In addition, SIRT1 activation elicits resistance to oxidative stress via the regulation of transcription factors and co-activators such as FOXO, Hif-2a, and NF-kB. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically at Lysine 382. This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human SIRT1.
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