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货号: TPFL0122
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: SLC7A11
应用: WB, IHC, IF/ICC, IP, ELISA
反应性 : human
宿主物种 : Rabbit
MW(CalcμLated) : 55 kDa
MW(Observed): 35-40 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 450 ug/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : SLC7A11
蛋白名称 : solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
别名 : SLC7A11, xCT, Amino acid transport system xc, Amino acid transport system xc-, CCBR1
背景:
SLC7A11 (also known as xCT) is a membrane transporter involved in the uptake of cystine. It promotes glutathione synthesis through the uptake of cystine and the concomitant release of glutamate. This, in turn, protects cells from oxidative stress, maintains cellular redox balance, and prevents cell death induced by lipid peroxidation. SLC7A11 has been identified as a potential target for cancer therapeutics. It is overexpressed in multiple malignant tumors and is closely associated with the growth, prognosis, metastasis, and treatment response of various cancers including lung cancer. The SLC7A11 protein appears at two molecular weights, 55 kDa and 35 kDa, and the 55 kDa protein is ubiquitinated(PMID: 32188872). 26864-1-AP recognizes the 35-40 kDa protein similar to the paper published (PMID: 36747082).


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