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货号: TPFL0105
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: KDR
应用: WB, IHC, IF-P, IP, ELISA
反应性 : human, mouse, rat
宿主物种 : Rabbit
MW(CalcμLated) : 1356 aa, 152 kDa
MW(Observed): 180-200 kDa, 230 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 750 ug/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : KDR
蛋白名称 : kinase insert domain receptor (a type III receptor tyrosine kinase)
别名 : KDR, VEGFR2, CD309, EC:2.7.10.1, FLK-1
背景:
KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.


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