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货号: TPFL0103
货期: 现货
价格: 1350;2200;3000
所属分类:
靶点: WNT3A
应用: WB, ELISA
反应性 : human, mouse
宿主物种 : Rabbit
MW(CalcμLated) : 352 aa, 39 kDa
MW(Observed): 42 kDa
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
组成 : PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
纯化工艺 : Antigen affinity purification
储存 : Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage.
浓度 : 550 ug/ml
克隆性 : Polyclonal
抗原&靶点信息
基因名称 : WNT3A
蛋白名称 : wingless-type MMTV integration site family, member 3A
别名 : Protein Wnt 3a, Protein Wnt-3a
背景:
WNT3A belongs to wingless-type MMTV integration site family, and abnormal Wnt signalling is often associated with severe human diseases, including cancer, osteoporosis and other degenerative disorders. WNT3A is a secreted glycoprotein that is involved in both canonical and non-canonical Wnt signaling pathways. The canonical Wnt pathway, also known as the β-catenin-dependent pathway, regulates gene expression by stabilizing β-catenin, which then translocates to the nucleus and interacts with transcription factors like TCF/LEF. It's shown to promote trophectoderm formation in embryonic stem cells. It's reported that the canonical Wnt/β-catenin signaling pathway also contributes to the carcinogenesis and progression of lung cancer cell lines. The non-canonical pathways, which are β-catenin-independent, are involved in cytoskeletal organization and cell polarity.


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