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货号: TPFL0076
货期: 现货
价格: 790;1240;1990;3790
所属分类：
靶点: Protein c-Fos; Cellular oncogene fos; Fos proto-oncogene
应用： WB, IP, IHC, IF, ChIP
反应性 ： Human, Mouse, Rat
宿主物种 ： Rabbit
同种型-Isotype ： IgG
偶联-Conjugate ： Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:1000
组成 ： PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3
储存 ： -20°C (avoid freeze-thaw cycles), 2 years
克隆性 ： Monoclonal
克隆号 ： B8E19
抗原&靶点信息
特异性 ： c-Fos Antibody (Rabbit mAb) [B8E19]
基因名称 ： FOS
蛋白名称 ： Protein c-Fos
别名 ： Protein c-Fos; Cellular oncogene fos; Fos proto-oncogene, AP-1 transcription factor subunit; G0/G1 switch regulatory protein 7; Proto-oncogene c-Fos; Transcription factor AP-1 subunit c-Fos; FOS; G0S7
背景：
c-Fos is a member of the Fos family of nuclear oncogenes, which also includes FosB, Fos-related antigen 1 (FRA1), and Fos-related antigen 2 (FRA2). As a nuclear phosphoprotein, c-Fos is characterized by its basic leucine zipper (bZIP) domain, which consists of a basic DNA-binding region adjacent to a leucine zipper motif, enabling it to form heterodimers with Jun proteins, thereby constituting the activator protein-1 (AP-1) transcription factor complex. c-Fos contains distinct N-terminal and C-terminal transcriptional activation domains, including motifs such as HOB1 and HOB2, which are essential for its transcriptional activity and oncogenic transformation. Additionally, an extra N-terminal transcriptional activation domain is indispensable for its full transforming potential. c-Fos is classified as an immediate early gene that can be rapidly and transiently induced by a variety of extracellular stimuli, such as growth factors, cytokines, and stress signals. c-Fos regulates the expression of genes related to cell proliferation, differentiation, survival, angiogenesis, and epithelial-mesenchymal transition through AP-1, making it a key regulator in development and tumorigenesis. Phosphorylation by kinases such as Erk enhances c-Fos stability and promotes its nuclear localization, further augmenting its transcriptional activity. c-Fos only forms heterodimers with Jun family proteins (c-Jun, JunB, JunD) and cannot form homodimers, and different Fos/Jun heterodimers exhibit distinct transcriptional activation capabilities. Aberrant regulation of c-Fos expression or phosphorylation leads to tumor transformation and cancer progression.
细胞定位 ： Cytoplasm, endoplasmic reticulum, nucleus
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