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货号: TPFL0062
货期: 现货
所属分类：
靶点: NCAM1
应用： W, IP, IHC-Bond, IHC-P, IF-F, IF-IC, FC-FP
反应性 ： H M R Mk
宿主物种 ： Rabbit
MW(Observed)： 120 to 220
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
推荐稀释比 ： Application Dilution Western Blotting 1:1000 Immunoprecipitation 1:50 IHC Leica Bond 1:50 - 1:200 Immunohistochemistry (Paraffin) 1:100 - 1:400 Immunofluorescence (Frozen) 1:50 - 1:100 Immunofluorescence (Immunocytochemistry) 1:50 - 1:100 Flow Cytometry (Fixed/Permeabilized) 1:200 - 1:800
来源 ： Rabbit
纯化工艺 ： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro799 of human NCAM1/CD56 protein.
储存 ： Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 88856 .
克隆性 ： Monoclonal
克隆号 ： E7X9M
抗原&靶点信息
特异性 ： NCAM1 (CD56) (E7X9M) Rabbit Monoclonal Antibody recognizes endogenous levels of total NCAM1/CD56 protein.
背景：
NCAM (neural cell adhesion molecule, CD56) is an adhesion glycoprotein with five extracellular immunoglobulin-like domains followed by two fibronectin type III repeats. Structural diversity is introduced by alternative splicing resulting in different cytoplasmic domains (1). NCAM mediates neuronal attachment, neurite extension, and cell-cell interactions through homo and heterophilic interactions. PSA (polysialic acid) post-translationally modifies NCAM and increases the metastatic potential of small cell lung carcinoma, Wilms' tumor, neuroblastoma, and rhabdomyosarcoma (2). CD56 is commonly used along with CD3 and CD16 to identify human natural killer (NK) cells (mouse NK cells do not express CD56) (3). Human NK cells are CD3-CD56+. The large subset with high CD16 expression are mature cytotoxic NK cells, while those with low CD16 expression are immature precursors and cytokine producers (4,5).
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