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货号: TPFL0057
货期: 现货
价格: 790;1240;1990;3790
所属分类：
靶点: MAPK 14
应用： WB, IHC, IF, FCM
反应性 ： Human, Mouse, Rat, Hamster, Monkey, Bovine, Pig
宿主物种 ： Rabbit
MW(CalcμLated) ： 40 kDa
同种型-Isotype ： IgG
偶联-Conjugate ： Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:1000
组成 ： PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN₃
储存 ： –20°C (avoid freeze-thaw cycles), 2 years
克隆性 ： Monoclonal
克隆号 ： N23C2
抗原&靶点信息
特异性 ： p38 MAPK Antibody (Rabbit mAb) [N23C2]
别名 ： CSAID-binding protein | Csaids binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | cytokine suppressive anti-inflammatory drug binding protein | Cytokine suppressive anti-inflammatory drug-binding protein | ERK-6 | ERK3 | ERK6 | EXIP | Extracellular signal-regulated kinase 6 | MAP kinase 11 | MAP kinase 12 | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAP kinase p38 beta | MAP kinase p38 gamma | MAPK 11 | MAPK 12 | MAPK 14 | MAPK11 | MAPK12 | MAPK14 | MAX-interacting protein 2 | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase 12 | Mitogen-activated protein kinase 14 | mitogen-activated protein kinase 3 | Mitogen-activated protein kinase p38 alpha | Mitogen-activated protein kinase p38 beta | Mitogen-activated protein kinase p38 gamma | mitogen-activated protein kinase p38-2 | MK11 | MK12 | MK14 | MXI2 | p38 | p38 MAP kinase | p38 mitogen activated protein kinase | p38-2 | p38-alpha | P38A | p38ALPHA | p38alpha Exip | p38b | p38Beta | P38BETA2 | P38G | P38GAMMA | PRKM11 | PRKM12 | PRKM14 | PRKM15 | RK | SAPK-3 | SAPK2 | SAPK2A | SAPK2B | SAPK3 | Stress-activated protein kinase 2 | stress-activated protein kinase 2A | Stress-activated protein kinase 2b | Stress-activated protein kinase 3 | stress-activated protein kinase-2 | stress-activated protein kinase-2b
背景：
The p38 family is highly conserved across species and consists of mitogen-activated protein kinases (MAPKs) that participate in coordinating cellular responses to various stress stimuli. p38α was initially identified as a 38 kDa protein that undergoes tyrosine phosphorylation upon LPS stimulation and shares homology with the osmotic response protein kinase HOG1 in Saccharomyces cerevisiae. It is also known as cytokine-suppressive anti-inflammatory drug binding protein (CSBP) due to its targeting by anti-inflammatory compounds; and as reactivating kinase (RK) due to its activation of MK2. Mammals have four p38 isoforms: p38α (MAPK14), p38β (MAPK11, SAPK2b), p38γ (MAPK12, ERK6, SAPK3), and p38δ (MAPK13, SAPK4). Activation of p38 involves a kinase cascade: MAP3K activates MAP2K, which then activates MAPK. MKK3 and MKK6 are the main upstream kinases that activate p38 and can phosphorylate most p38 isoforms in vitro.
细胞定位 ： Cytoplasm, nucleus, mitochondrion
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