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货号: TPFL0054
货期: 现货
价格: 790;1240;1990;3790
所属分类：
靶点: Insulin-like growth factor 1 receptor
应用： WB, IP
反应性 ： Human
宿主物种 ： Rabbit
MW(CalcμLated) ： 95 kDa
同种型-Isotype ： IgG
偶联-Conjugate ： Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:1000
组成 ： PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3
储存 ： -20°C (avoid freeze-thaw cycles), 2 years
克隆性 ： Monoclonal
克隆号 ： J6K20
抗原&靶点信息
特异性 ： Phospho-IGF-1R β (Y1131)/IR β (Y1146) Antibody (Rabbit mAb) [J6K20]
基因名称 ： IGF1R
蛋白名称 ： Insulin-like growth factor 1 receptor
别名 ： Insulin-like growth factor 1 receptor, Insulin-like growth factor I receptor (IGF-I receptor), CD221, IGF1R
背景：
The vascular insulin-like growth factor-1 (IGF-1) system is composed of IGFs, the IGF-1 receptor (IGF-1R), and a series of IGF-binding proteins. This growth factor network acts through endocrine and autocrine/paracrine pathways, influencing a variety of vascular functions. Although IGF-1 activity is primarily mediated by IGF-1R, its activity is also finely regulated by IGF-binding proteins, whose functions are modulated through phosphorylation, proteolysis, polymerization, and binding to cells or the extracellular matrix. The expression of IGF system components is controlled by multiple stimulatory factors, including other growth factors, cytokines, lipoproteins, reactive oxygen species, and hemodynamic factors. Moreover, cross-talk has been observed between the IGF system and various growth factor pathways, as well as integrin receptors. In humans, IGF-1R is encoded by a single-copy gene located on chromosome 15 and is widely expressed. The mature receptor is a tetramer composed of two extracellular α chains and two intracellular β chains. The β chain contains an intracellular tyrosine kinase domain that is essential for most receptor-mediated biological functions. Upon IGF-1 binding, IGF-1R undergoes autophosphorylation, followed by tyrosine phosphorylation of adaptor proteins such as Shc and insulin receptor substrates (IRS-1, IRS-2, IRS-3, and IRS-4). IRS proteins act as docking platforms, triggering multiple downstream signaling cascades, particularly the phosphatidylinositol 3-kinase (PI3K), Akt, and mitogen-activated protein kinase (MAPK) pathways. These signaling events lead to distinct cellular responses, including proliferation, differentiation, migration, and survival. Initial autophosphorylation within the IGF-1R kinase domain occurs at three critical tyrosine residues—Tyr1131, Tyr1135, and Tyr1136. The insulin receptor (IR) is highly similar in structure and function to IGF-1R and also possesses a similar cluster of tyrosines—Tyr1146, Tyr1150, and Tyr1151—within the activation loop of its kinase domain.
细胞定位 ： Cell membrane, endomembrane system
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