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货号: TPFL0047
货期: 现货
价格: 790;1240;1990;3790
所属分类：
靶点: Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau (PHF-tau); MAPT; MAPTL; MTBT1; TAU
应用： WB, IP, IHC, IF
反应性 ： Human, Mouse, Rat
宿主物种 ： Rabbit
MW(CalcμLated) ： 50-80 kDa
同种型-Isotype ： IgG
偶联-Conjugate ： Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:1000
组成 ： PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3
储存 ： -20°C (avoid freeze-thaw cycles), 2 years
克隆性 ： Monoclonal
克隆号 ： B1L14
抗原&靶点信息
特异性 ： Phospho-Tau (Thr181) Antibody (Rabbit mAb) [B1L14] 仅识别 Thr181
基因名称 ： MAPT
蛋白名称 ： Microtubule-associated protein tau
别名 ： Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau (PHF-tau); MAPT; MAPTL; MTBT1; TAU
背景：
Phosphorylated Tau protein (Thr181) is a form of microtubule-associated protein Tau, in which threonine residue 181 is phosphorylated, and this site is located within the proline-rich region (PRR) of Tau protein. There are six isoforms of Tau protein, which differ in the number of N-terminal inserts and C-terminal microtubule-binding repeats. Structurally, Tau protein contains an N-terminal projection domain that separates microtubules, a PRR region rich in phosphorylation sites and kinase interactions, and a C-terminal domain that contains three to four microtubule-binding repeats, responsible for binding to microtubules to promote tubulin polymerization and axonal stability. Phosphorylation at Thr181 reduces the affinity of Tau protein for microtubules, leading to cytoskeletal disassembly. Multiple kinases, including GSK-3, CDK5, and ERK, target Thr181 and its neighboring residues, with approximately 25 phosphorylation sites, which promote the detachment of tau protein from microtubules and subsequent aggregation to form paired helical filaments (PHF). These aggregates form neurofibrillary tangles, a pathological hallmark of Alzheimer's disease (AD), and are closely associated with neuronal loss. Tau protein inclusions are also found in other tauopathies, such as frontotemporal dementia. Elevated levels of phosphorylated Thr181 tau protein in cerebrospinal fluid (CSF) can serve as an early biomarker for AD, often detectable before the appearance of neurofibrillary tangle pathology, and are correlated with the accumulation of β-amyloid. Pathologically phosphorylated tau protein impairs axonal transport, disrupts synaptic function, and activates neuroinflammatory pathways, particularly through the GSK-3 signaling pathway.
细胞定位 ： Cell membrane, cell projection, cytoplasm, cytoskeleton, endomembrane system, microtubule, extracellular environment
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