产品服务
信号通路
货号: TPFL0043
货期: 现货
价格: 790;1240;1990;3790
所属分类：
靶点: RUNX2
应用： WB, IP, IHC, ChIP
反应性 ： Human, Mouse, Rat
宿主物种 ： Rabbit
MW(CalcμLated) ： 60 kDa, 64 kDa
同种型-Isotype ： IgG
偶联-Conjugate ： Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:1000
组成 ： PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN₃
储存 ： -20°C (avoid freeze-thaw cycles), 2 years
克隆性 ： Monoclonal
克隆号 ： F19J12
抗原&靶点信息
特异性 ： RUNX2 Antibody (Rabbit mAb) [F19J12]
基因名称 ： RUNX2
蛋白名称 ： Runt-related transcription factor 2
别名 ： AML3 | CBFA1 | OSF2 | PEBP2A | RUNX2 | Runt-related transcription factor 2 | Acute myeloid leukemia 3 protein | Core-binding factor subunit alpha-1 | Oncogene AML-3 | Osteoblast-specific transcription factor 2 | Polyomavirus enhancer-binding protein 2 alpha A subunit | SL3-3 enhancer factor 1 alpha A subunit | SL3/AKV core-binding factor alpha A subunit | CBF-alpha-1 | OSF-2 | PEA2-alpha A | PEBP2-alpha A
背景：
RUNX2 (Runt-related transcription factor 2) is a key transcription factor in skeletal development, primarily known for its role in osteoblast differentiation and bone formation. It acts as a master regulator, guiding mesenchymal stem cells (MSCs) toward the osteoblast lineage by activating key genes that are important components of the bone extracellular matrix, such as type I collagen (Col1), osteocalcin (OCN), and osteopontin (OPN). RUNX2 is essential for both intramembranous ossification (where bone forms directly from mesenchymal tissue) and endochondral ossification (which involves the replacement of cartilage by bone). During endochondral ossification, RUNX2 regulates the maturation of hypertrophic chondrocytes and promotes the expression of type X collagen (Col10a), facilitating the conversion of cartilage to bone. Furthermore, RUNX2 also influences the production and mineralization of bone matrix during osteoblast maturation. It plays a significant role in regulating osteoclastogenesis by modulating genes such as osteoprotegerin (OPG) and RANKL, maintaining the balance between bone formation and bone resorption, thereby preserving bone homeostasis. It is also involved in angiogenesis by regulating vascular endothelial growth factor (VEGF), promoting blood vessel formation in bone tissue. Dysregulation or mutations of RUNX2 can lead to various skeletal disorders, including cleidocranial dysplasia (CCD), osteoporosis, and osteosarcoma.
细胞定位 ： Cytoplasm, nucleus
推荐产品
相关文献
我们始终开放沟通，期待为您提供支持。
我们以一抗、二抗产品为核心，深耕抗体试剂细分领域。依托自主搭建的核心技术平台与专业的研发生产团队，我们为全球高校、科研院所、生物医药企业等客户提供高可靠性的生物试剂产品及全链条技术
支持服务。自成立以来，Pinofibio 始终坚守“以科研需求为导向”的发展理念，通过完善的研发体系、严苛的质量控制与高效的服务响应，致力于构建覆盖多物种、多靶点的抗体产品矩阵，助力科研工作者攻克技术难题，推动生物医药产业的创新发展。
武汉市皮诺飞生物科技有限公司
地址：湖北省武汉市江夏区神墩四路 666 号武汉国英种业大厦A栋14F
邮箱：pinuofei2017@163.com
TEL：15392937510
小红书
实验服务
公众号
抗体服务
微信客服