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货号: TPFL0041
货期: 现货
价格: 790;1240;1990;3790
所属分类:
靶点: SOX9
应用: WB, IHC, IF, FCM
反应性 : Human, Mouse, Rat, Common marmoset, Cow, Dog, Pig
宿主物种 : Rabbit
同种型-Isotype : IgG
偶联-Conjugate : Unconjugated
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:1000
组成 : PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN₃
储存 : –20°C (avoid freeze-thaw cycles), 2 years
克隆性 : Monoclonal
克隆号 : J19L1
抗原&靶点信息
特异性 : SOX9 Antibody (Rabbit mAb) [J19L1]
基因名称 : SOX9
蛋白名称 : Transcription factor SOX-9
别名 : CMD1 | CMPD1 | SOX9 | SRA1 | SRXX2 | SRXY10 | SRY (sex determining region Y)-box 9 | SRY (sex determining region Y)-box9 | SRY (sex-determining region Y)-box 9 protein | SRY-box 9 | SRY-box transcription factor 9 | SRY-related HMG-box | gene 9 | Transcription factor SOX-9 | transcription factor SOX9
背景:
SOX9, also known as SRY-Box transcription factor 9, is a key transcription factor in the family of 20 SRY-related HMG box (SOX) proteins. These proteins regulate various developmental pathways related to stem cells, differentiation, and progenitor cell development. SOX9 is crucial for organogenesis during mammalian embryonic development and also coordinates with steroidogenic factor-1 (SF-1) to promote Sertoli cell-specific expression of anti-Müllerian hormone (AMH) during embryogenesis, thereby contributing to male sex determination. Mutations in the human SOX9 gene cause campomelic dysplasia, a disease of haploinsufficiency nature with multiple skeletal malformations, often accompanied by 46,XY or sex development disorders.


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