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货号: TPFL0027
货期: 现货
价格: 3347.06
所属分类：
靶点: CD8 alpha
应用： Flow Cyt, IP, WB, IHC-P, IHC-Fr
反应性 ： Mouse
宿主物种 ： Rabbit
MW(CalcμLated) ： 26 kDa
MW(Observed)： 34 kDa; 38 kDa; 35 kDa
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
推荐稀释比 ： IP: 1/30；Flow Cyt: 1/500；WB: 1/1000；IHC-Fr: 1/500；IHC-P: 1/2000
组成 ： pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
纯化工艺 ： Affinity purification Protein A
储存 ： Form: Liquid，Shipping condition: Blue Ice，Short-term storage (1–2 weeks): +4°C，Long-term storage: -20°C，Aliquot information:，Aliquot upon delivery，Storage note: Avoid freeze-thaw cycles.
克隆性 ： Monoclonal
克隆号 ： EPR21769
抗原&靶点信息
基因名称 ： Cd8a
蛋白名称 ： T-cell surface glycoprotein CD8 alpha chain
别名 ： CD8a, Lyt-2, Lyt2, Cd8a, T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein Lyt-2
背景：
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule : peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
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