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货号: STA00540
货期: 次日发货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类:
靶点: Phospho-TrkB
应用: WB IHC ICC/IF IP
反应性 : Human Mouse Rat
宿主物种 : Rabbit
MW(Observed): 140kDa
同种型-Isotype : IgG
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:500~1:1000 IHC 1:50~1:100 ICC/IF 1:50~1:100 IP 1:30
纯化工艺 : Affinity-chromatography
储存 : Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
克隆性 : Monoclonal
抗原&靶点信息
特异性 : Phospho-TrkB (Y817) Antibody detects endogenous levels of Phospho-TrkB (Y817)
别名 : NTRK2; gp145-TrkB; Trk-B; TRKB; Tropomyosin-related kinase B; TrkB tyrosine kinase; Tyrosine kinase receptor B;
数据库链接:
背景:
The family of Trk receptor tyrosine kinases consists of TrkA, TrkB and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. TrkA regulates proliferation and is important for development and maturation of the nervous system. Point mutations, deletions and chromosomal rearrangements (chimeras) cause ligand-independent receptor dimerization and activation of TrkA.


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