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货号: STA00459
货期: 次日发货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类:
靶点: KDM1/LSD1
应用: WB IHC ICC/IF IP
反应性 : Human Mouse Rat
宿主物种 : Rabbit
MW(Observed): 110kDa
同种型-Isotype : IgG
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:1000~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:30
纯化工艺 : Affinity-chromatography
储存 : Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
克隆性 : Monoclonal
抗原&靶点信息
特异性 : KDM1 / LSD1 Antibody detects endogenous levels of total KDM1 / LSD1
别名 : KDM1;AOF2;BHC110;KIAA0601;LSD1; KDM1A;
数据库链接:
背景:
Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes.


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