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货号: STA00755
货期: 次日发货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类:
靶点: Cyclin
应用: WB ICC/IF
反应性 : Human
宿主物种 : Rabbit
MW(Observed): 47kDa
同种型-Isotype : IgG
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:1000~1:2000 ICC/IF 1:50~1:200
纯化工艺 : Affinity-chromatography
储存 : Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
克隆性 : Monoclonal
抗原&靶点信息
特异性 : Cyclin E1 Antibody detects endogenous levels of Cyclin E1
别名 : CCNE; Ccne1; cyclin E variant ex5del; cyclin E variant ex7del; Cyclin E1; Cyclin Es; Cyclin Et; G1/S specific cyclin E; G1/S-specific cyclin-E1;
数据库链接:
背景:
Cyclin E1 and cyclin E2 can associate with and activate CDK2. Upon DNA damage, upregulation/activation of the CDK inhibitors p21 Waf1/Cip1 and p27 Kip1 prevent cyclin E/CDK2 activation, resulting in G1/S arrest. Cyclin E1 is phosphorylated at multiple sites in vivo including Thr62, Ser88, Ser72, Thr380 and Ser384, and is controlled by at least two kinases, CDK2 and GSK-3.


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