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货号: STA00179
货期: 次日发货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类:
靶点: BMP4
应用: WB IHC ICC/IF IP FC
反应性 : Human
宿主物种 : Rabbit
MW(Observed): 47kDa
同种型-Isotype : IgG
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50 FC 1:50
纯化工艺 : Affinity-chromatography
储存 : Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
克隆性 : Monoclonal
抗原&靶点信息
特异性 : BMP4 Antibody detects endogenous levels of total BMP4
别名 : BMP-2B; BMP-4; BMP2B; BMP2B1; bone morphogenetic protein 4; DVR4; ZYME
数据库链接:
背景:
Bone morphogenetic proteins (BMPs) were first identified as molecules that can induce ectopic bone and cartilage formation. BMPs belongs to the TGF-β superfamily, playing many diverse functions during development. BMPs are synthesized as precursor proteins and then processed by cleavage to release the c-terminal mature BMP. BMPs initiate signaling by binding to a receptor complex containing type I and type II serine/threonine receptor kinases that then phosphorylate Smad (mainly Smad1, 5 and 8), resulting the translocation of Smad into the nucleus. BMP was also reported to activate MAPK pathways in some systems.


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