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货号: PG7714
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类:
靶点: NPL4
应用: WB,ELISA
反应性 : Human,Rat,Mouse
宿主物种 : Rabbit
MW(Observed): 66kD
同种型-Isotype : IgG
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:500-2000;ELISA 1:5000-20000
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal
抗原&靶点信息
特异性 : NPL4 Polyclonal Antibody detects endogenous levels of protein.
基因名称 : NPLOC4 KIAA1499 NPL4
蛋白名称 : Nuclear protein localization protein 4 homolog (Protein NPL4)
背景:
domain:Binds ubiquitinated proteins via its RanBP2-type zinc finger.,function:The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope.,pathway:Protein degradation; proteasomal ubiquitin-dependent pathway.,similarity:Belongs to the NPL4 family.,similarity:Contains 1 RanBP2-type zinc finger.,subcellular location:Associated with the endoplasmic reticulum and nuclear.,subunit:Heterodimer with UFD1L. The heterodimer binds ubiquitinated proteins. The heterodimer binds to VCP and inhibits Golgi membrane fusion.,tissue specificity:Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver.,


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