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ERCC1 (PT0756) mouse mAb

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说明书下载
货号: PH0637
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
+


靶点: ERCC1
应用: WB,IF,ELISA
反应性 : Human,
宿主物种 : Mouse
MW(CalcμLated) : 33kD
MW(Observed): 33kD
同种型-Isotype : IgG1,Kappa

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein G
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
克隆号 : PT0756

抗原&靶点信息

特异性 : This antibody detects endogenous levels of ERCC1 protein.
基因名称 : ERCC1
蛋白名称 : ERCC1
别名 : DNA excision repair protein ERCC-1

数据库链接:

Organism

基因 ID

SwissProt

背景:

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein ge

细胞定位 : Nuclear

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