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货号: PG8214
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类：
靶点: BOK
应用： WB,ELISA
反应性 ： Human,Mouse,Rat
宿主物种 ： Rabbit
MW(Observed)： 23kD
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:500-2000;ELISA 1:5000-20000
组成 ： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
浓度 ： 1 mg/ml
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： BOK Polyclonal Antibody detects endogenous levels of protein.
基因名称 ： BOK BCL2L9
蛋白名称 ： Bcl-2-related ovarian killer protein (hBOK) (Bcl-2-like protein 9) (Bcl2-L-9)
背景：
The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 2011],
细胞定位 ： [Isoform 1]: Mitochondrion membrane ; Single-pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein . Mitochondrion inner membrane . Cytoplasm . Nucleus . Mitochondrion . Endoplasmic reticulum . Mitochondrion outer membrane . Early endosome membrane . Recycling endosome membrane . Nucleus outer membrane . Golgi apparatus, cis-Golgi network membrane . Golgi apparatus, trans-Golgi network membrane . Membrane . Nuclear and cytoplasmic compartments in the early stages of apoptosis and during apoptosis it associates with mitochondria (PubMed:19942931). In healthy cells, associates loosely with the membrane in a hit-and-run mode. The insertion and accumulation on membranes is enhanced through the activity of death signals, resulting in the integration of the membrane-bound protein into the membrane (PubMed:15868100). The transmembrane domain controls subcellular localization; constitutes a tail-anchor. Localizes in early and late endosome upon blocking of apoptosis. Must localize to the mitochondria to induce mitochondrial outer membrane permeabilization and apoptosis (By similarity). .; [Isoform 2]: Membrane . Cytoplasm .
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