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货号: PH1331
货期: 一周
价格: 100μL/2200
所属分类：
靶点: SOX-2
应用： WB
反应性 ： Human,Mouse,Rat,Bovine,Pig,sheep
宿主物种 ： Mouse
MW(CalcμLated) ： 34kD
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:1000-1:2000;Not yet tested in other applications.
组成 ： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 ： Affinity purification
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 ： Monoclonal
抗原&靶点信息
特异性 ： SOX-2 Monoclonal Antibody detects endogenous levels of SOX-2 protein.
基因名称 ： SOX2
蛋白名称 ： Transcription factor SOX-2
别名 ： SOX2;Transcription factor SOX-2
背景：
SRY-box 2(SOX2) Homo sapiens This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008],
细胞定位 ： Nucleus speckle . Cytoplasm . Nucleus . Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity). .
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