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详细信息
推荐稀释比 : ELISA 1:5000-100000;Flow Cyt 1-2μg/Test
组成 : Phosphate-buffered solution
来源 : Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
纯化工艺 : Recombinant Expression and Affinity purified
储存 : -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
浓度 : Please check the information on the tube
克隆性 : Monoclonal
克隆号 : PN0359
抗原&靶点信息
特异性 : This recombinant monoclonal antibody can detects endogenous levels of CD337 protein.
基因名称 : NCR3 1C7 LY117
蛋白名称 : C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183)
别名 : CXCR3;G protein-coupled receptor 9;GPR9;CKR-L2;IP10 receptor;IP10-R;Mig receptor;Mig-R;C-X-C chemokine receptor type 3 antibody;CD 183 antibody;CD182 antibody;CD183 antibody;Chemokine;C X C motif;receptor 3 antibody;Chemokine;C X C;receptor 3 antibody;Chemokine CXC Motif Receptor 3 antibody;CKR L2 antibody;CKR-L2 antibody;CKRL2 antibody;CMKAR3 antibody;CXC-R3 antibody;CXCR-3 antibody;CXCR3 antibody;CXCR3_HUMAN antibody;G Protein Coupled Receptor 9 antibody;G protein-coupled receptor 9 antibody;GPR9 antibody;Interferon-inducible protein 10 receptor antibody;IP-10 receptor antibody;IP10 antibody;IP10 R antibody;IP10 receptor antibody;IP10-R antibody;IP10R antibody;Mig R antibody;Mig receptor antibody;Mig-R antibody;MIGR antibody;
背景:
The p30-15 monoclonal antibody recognizes CD337 also known as activating NK receptor NKp30 (NKp30), and natural cytotoxicity triggering receptor 3. NKp30 is a type I transmembrane protein, member of the natural cytotoxicity receptor family that contains one immunoglobulin-like domain. NKp30 has an apparent molecular weight of 30 kD and six isoforms are produced by alternative splicing. NKp30 is expressed on resting and activated NK cells. NKp30 enhances NK cell cytolysis of tumor cellts that are deficient in MHC class I molecules. NKp30 has been shown to associate with CD59 and TCRζ. The p30-15 antibody against human NKp30 has been shown to be useful for flow cytometry, stimulation of human NK cells via NKp30 in a redirected lysis assay, and blocking of NKp30 function in solution.


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