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推荐稀释比 ： ELISA 1:5000-100000;Flow Cyt 1-2μg/Test
组成 ： Phosphate-buffered solution
来源 ： Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
纯化工艺 ： Recombinant Expression and Affinity purified
储存 ： -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
浓度 ： Please check the information on the tube
克隆性 ： Monoclonal
克隆号 ： PN0368
抗原&靶点信息
特异性 ： This recombinant monoclonal antibody can detects endogenous levels of CD337 protein.
基因名称 ： NCR3 1C7 LY117
蛋白名称 ： Low affinity immunoglobulin gamma Fc region receptor II-b
别名 ： CD32 antibody;CD32 antigen antibody;CD32B antibody;CDw32 antibody;Fc fragment of IgG;low affinity II;receptor for;CD32;antibody;Fc fragment of IgG;low affinity IIb;receptor antibody;Fc fragment of IgG;low affinity IIb;receptor;CD32;antibody;Fc fragment of IgG;low affinity IIb;receptor for;CD32;antibody;Fc fragment of IgG;low affinity IIb;receptor for antibody;Fc gamma receptor IIB antibody;Fc gamma RII antibody;Fc gamma RIIB antibody;Fc-gamma RII antibody;Fc-gamma RII-b antibody;Fc-gamma-RIIb antibody;FCG2 antibody;FCG2B_HUMAN antibody;Fcgr2 antibody;FCGR2B antibody;FCRII antibody;FcRII-b antibody;IGFR2 antibody;IgG Fc receptor II beta antibody;IgG Fc receptor II-b antibody;Low affinity immunoglobulin gamma Fc region receptor II antibody;Low affinity immunoglobulin gamma Fc region receptor II-b antibody;Ly-17 antibody;Lym 1 antibody;Lymphocyte antigen 17 antibody;CD32 nanobody;
背景：
The p30-15 monoclonal antibody recognizes CD337 also known as activating NK receptor NKp30 (NKp30), and natural cytotoxicity triggering receptor 3. NKp30 is a type I transmembrane protein, member of the natural cytotoxicity receptor family that contains one immunoglobulin-like domain. NKp30 has an apparent molecular weight of 30 kD and six isoforms are produced by alternative splicing. NKp30 is expressed on resting and activated NK cells. NKp30 enhances NK cell cytolysis of tumor cellts that are deficient in MHC class I molecules. NKp30 has been shown to associate with CD59 and TCRζ. The p30-15 antibody against human NKp30 has been shown to be useful for flow cytometry, stimulation of human NK cells via NKp30 in a redirected lysis assay, and blocking of NKp30 function in solution.
细胞定位 ： Cell membrane ; Single-pass type I membrane protein .
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