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c-Fgr Monoclonal Antibody

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说明书下载
货号: PH1755
货期: 一周
价格: 100μL/2200
+


靶点: c-Fgr
应用: WB,IHC,IF,ELISA
反应性 : Human,Mouse
宿主物种 : Mouse
MW(CalcμLated) : 59kD

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:500-1:2000;IHC 1:200-1:1000;ELISA 1:10000;IF 1:50-200
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : Affinity purification
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal

抗原&靶点信息

特异性 : c-Fgr Monoclonal Antibody detects endogenous levels of c-Fgr protein.
基因名称 : FGR
蛋白名称 : Tyrosine-protein kinase Fgr
别名 : FGR;SRC2;Tyrosine-protein kinase Fgr;Gardner-Rasheed feline sarcoma viral;v-fgr;oncogene homolog;Proto-oncogene c-Fgr;p55-Fgr;p58-Fgr;p58c-Fgr

数据库链接:

Organism

基因 ID

SwissProt

背景:

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008],

细胞定位 : Cell membrane ; Lipid-anchor ; Cytoplasmic side . Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Mitochondrion inner membrane . Mitochondrion intermembrane space . Detected in mitochondrial intermembrane space and at inner membranes (By similarity). Colocalizes with actin fibers at membrane ruffles. Detected at plasma membrane lipid rafts. .

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