产品服务
信号通路
说明书下载
货号: PD1492
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类:
靶点: S12A3
应用: WB
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(CalcμLated) : 112kD
同种型-Isotype : IgG
隐藏域元素占位
详细信息
推荐稀释比 : WB 1:500-2000
组成 : Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
纯化工艺 : The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Polyclonal
抗原&靶点信息
特异性 : This antibody detects endogenous levels of S12A3 at Human/Mouse/Rat
基因名称 : SLC12A3 TSC
蛋白名称 : S12A3
背景:
This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],


微信客服