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货号: PG3262
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类：
靶点: ERK 5
应用： WB,IHC,IF
反应性 ： Human,Mouse,Rat
宿主物种 ： Rabbit
MW(Observed)： 89-115kD
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
推荐稀释比 ： WB 1:1000-2000;IHC 1:200-500;IF 1:50-200
组成 ： PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： The antibody detects endogenous ERK 5 protein.
基因名称 ： MAPK7,ERK5
蛋白名称 ： Mitogen-activated protein kinase 7
别名 ： MAPK7;BMK1;ERK5;PRKM7;Mitogen-activated protein kinase 7;MAP kinase 7;MAPK 7;Big MAP kinase 1;BMK-1;Extracellular signal-regulated kinase 5;ERK-5
背景：
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
细胞定位 ： Cytoplasm. Nucleus. Nucleus, PML body. Translocates to the nucleus upon activation.
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