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货号: PG3333
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类：
靶点: TLR1
应用： IHC,IF
反应性 ： Human,Mouse,Rat
宿主物种 ： Rabbit
同种型-Isotype ： IgG
隐藏域元素占位
详细信息
推荐稀释比 ： IHC 1:200-500;IF 1:50-200
组成 ： PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
纯化工艺 ： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
储存 ： -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 ： Polyclonal
抗原&靶点信息
特异性 ： The antibody detects endogenous TLR1 protein.
基因名称 ： TLR1
蛋白名称 ： Toll-like receptor 1
别名 ： TLR1;KIAA0012;Toll-like receptor 1;Toll/interleukin-1 receptor-like protein;TIL;CD281
背景：
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008],
细胞定位 ： Cell membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, phagosome membrane ; Single-pass type I membrane protein . Membrane raft . Golgi apparatus . Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. .
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