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推荐稀释比 ： ELISA 1:5000-100000
组成 ： Phosphate-buffered solution
来源 ： Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
纯化工艺 ： Recombinant Expression and Affinity purified
储存 ： -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
浓度 ： Please check the information on the tube
克隆性 ： Monoclonal
克隆号 ： PN0503
抗原&靶点信息
特异性 ： This recombinant monoclonal antibody can detects endogenous levels of CD274/PD-L1 protein.
基因名称 ： CD274 B7H1 PDCD1L1 PDCD1LG1 PDL1
蛋白名称 ： CD83 antigen (hCD83) (B-cell activation protein) (Cell surface protein HB15) (CD antigen CD83)
别名 ： CD83;CD83 antigen;hCD83;B-cell activation protein;Cell surface protein HB15;CD antigen CD83;CD83 nanobody;
背景：
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction ofThis ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue,This interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments,This interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression ofThis gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
细胞定位 ： Cell membrane ; Single-pass type I membrane protein . Early endosome membrane ; Single-pass type I membrane protein . Recycling endosome membrane ; Single-pass type I membrane protein . Associates with CMTM6 at recycling endosomes, where it is protected from being targeted for lysosomal degradation. .; [Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Endomembrane system ; Single-pass type I membrane protein .
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