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推荐稀释比 ： ELISA 1:5000-100000;Flow Cyt 1-2μg/Test
组成 ： Phosphate-buffered solution
来源 ： Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
纯化工艺 ： Recombinant Expression and Affinity purified
储存 ： -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
浓度 ： Please check the information on the tube
克隆性 ： Monoclonal
克隆号 ： PN0228
抗原&靶点信息
特异性 ： This recombinant monoclonal antibody can detects endogenous levels of CD72 protein.
基因名称 ： CD72
蛋白名称 ： Carcinoembryonic antigen-related cell adhesion molecule 8 (CD67 antigen) (Carcinoembryonic antigen CGM6) (Non-specific cross-reacting antigen NCA-95) (CD antigen CD66b)
别名 ： Carcinoembryonic antigen CGM6 antibody;Carcinoembryonic antigen gene family member 6 antibody;Carcinoembryonic antigen related cell adhesion molecule 8 antibody;Carcinoembryonic antigen-related cell adhesion molecule 8 antibody;CD 66b antibody;CD 67 antibody;CD66b antibody;CD66b antigen antibody;CD67 antibody;CD67 antigen antibody;CEACAM 8 antibody;CEACAM8 antibody;CEAM8_HUMAN antibody;CGM 6 antibody;CGM6 antibody;NCA 95 antibody;NCA95 antibody;Non-specific cross-reacting antigen NCA-95 antibody;Nonspecific cross reacting antigen NCA 95 antibody;Nonspecific cross reacting antigen NCA95 antibody;CD66b nanobody;
背景：
CD72 is a disulfide-linked homodimer belonging to C-type lectin family. CD72 is a pan-B cell marker expressed on pre-pre-B cells throughout B cell differentiation with the exception of plasma cells. It is also expressed on follicular dendritic cells, splenic red pulp macrophages (but not on peripheral blood monocytes), and liver Kupffer cells. CD72, a negative coreceptor of B cells, contains immunoreceptor tyrosine-based inhibitory motifs in the cytoplasmic domain which has been shown to recruit the tyrosine phosphatase SHP-1. Ligation of CD72 with its ligand regulates CD72 tyrosine dephosphorylation and SHP-1 dissociation to promote B cell activation and proliferation. CD100 and CD5 have been shown to be CD72 ligands. The CD100-CD72 interaction plays a role in maintenance of B cell homeostasis.
细胞定位 ： Membrane; Single-pass type II membrane protein.
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