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PDK1 Rabbit mAb

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说明书下载
货号: PL0496
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
+

所属分类:


靶点: PDK1
应用: WB,IF,IP,ELISA
反应性 : Human,Mouse,Rat
宿主物种 : Rabbit
MW(CalcμLated) : 49kD
MW(Observed): 49kD
同种型-Isotype : IgG,Kappa

隐藏域元素占位

详细信息

推荐稀释比 : WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein A
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
克隆性 : Monoclonal
克隆号 : PT1266R

抗原&靶点信息

特异性 : Endogenous
基因名称 : PDK1
蛋白名称 : [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1 mitochondrial
别名 : PDK1;PDHK1;[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1;mitochondrial;Pyruvate dehydrogenase kinase isoform 1

数据库链接:

Organism

基因 ID

SwissProt

背景:

Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2013],

细胞定位 : Catalytic activity:ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.,Function:Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.,similarity:Belongs to the PDK/BCKDK protein kinase family.,similarity:Contains 1 histidine kinase domain.,tissue specificity:Expressed predominantly in the heart.,

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