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货号: PF0111
货期: 现货
价格: 50μL/960;100μL/1600;200μL/2560
所属分类:
靶点: Lamin A/C (phospho Ser392)
应用: WB,IF,ELISA
反应性 : Human,Mouse,Rat,Monkey,
宿主物种 : Mouse
MW(CalcμLated) : 63kD,74kD
MW(Observed): 63kD,74kD
同种型-Isotype : IgG1,Kappa
隐藏域元素占位
详细信息
修饰-Modification : Phospho
推荐稀释比 : WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000
组成 : PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
纯化工艺 : Protein G
储存 : -15°C to -25°C/1 year(Do not lower than -25°C
浓度 : 1 mg/ml
克隆性 : Monoclonal
克隆号 : PTR1133
抗原&靶点信息
特异性 : This antibody detects endogenous levels of Lamin A/C (phospho Ser392) protein.
基因名称 : LMNA LMN1
蛋白名称 : Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
别名 : Prelamin-A/C [Cleaved into: Lamin-A/C;70 kDa lamin;Renal carcinoma antigen NY-REN-32;]
背景:
lamin A/C(LMNA) Homo sapiens The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012],


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